Endocrine Abstracts

We previously have reported that short-term treatment of mice with recombinant hGH leads to significant increases in bodyweight (BW), lean body mass (LBM) and liver weight, but – unlike in humans – does not robustly increase circulating levels of IGF1. We now tested the hypothesis that formation of neutralizing antibodies in mice treated with rhGH could explain the lack of IGF1 response. Therefore, we intentionally induced antibody formation against hGH in female FVB...

Mice overexpressing growth hormone (GH) have about two-fold higher IGF-I and clear increases in body and organ weights. Moreover, administration of GH to hypophysectomised or dwarf mice has been shown to increase IGF-I. Data on the short term effects of exogenous administration of rhGH in normal rodents remain scarce.Therefore, we measured IGF-I before and after one week of GH-treatment in 10-week-old female mice, injected daily with two different doses ...